Centerfielder David Calabrese swatted two home runs for the visiting Rocket City Trash Pandas, and the Lookouts lost 9-6 on Friday night.
Orlando Martinez and Kyren Paris also went deep for the Huntsville team.
Rocket City scored five in the second inning after Chattanooga went ahead 1-0. The Lookouts scored again in the bottom of the second.
However, the Trash Pandas got one in the fourth, two in the fifth, and another in the eighth as Lookouts starter Sam Benschoter fell to 0-3.
Noelvi Marte had three hits and James Free two for Chattanooga.
The two teams play a double header on Saturday.